17-OHP (17-hidroksiprogesteron)

17-OH progesterone (17-hydroxyprogesterone or OHP) is a hormone produced primarily by the adrenal glands, but also by the gonads, and is an important precursor (molecule that precedes the formation of another compound) in the synthesis of cortisol.

This test is used to assess adrenal function and diagnose disorders such as congenital adrenal hyperplasia (CAH), also known as adrenogenital syndrome (AGS). CAH (or CAH) is an inherited disorder, most often caused by a defect in the enzyme 21-hydroxylase, which interferes with the synthesis of cortisol and aldosterone. As a result, precursors such as 17-OH progesterone accumulate, leading to excessive production of androgens. This causes symptoms such as abnormal development of sexual characteristics, excessive hair growth, and acne. Symptoms vary depending on the patient's gender and age and can range from mild to severe.

High levels of 17-OH progesterone may indicate CAH, and the test is often used to monitor treatment for these conditions. Monitoring treatment for CAH involves measuring 17-OH progesterone levels to assess the effectiveness of treatment, usually hormone replacement therapy with cortisol. Effective treatment normalizes 17-OH progesterone and androgen levels, thereby controlling the progression of symptoms.

This test is particularly important in newborns and children, where it allows for early detection of CAH and the prevention of serious complications such as disorders of the development of sexual characteristics.

The test is done on a blood sample, and elevated levels may require additional testing and adjustment of therapy to control the hormonal disorders associated with 21-hydroxylase deficiency.